
Silent Partners: How a Dormant Phage Helps Listeria Outsmart the Immune System
In a surprising twist of microbial teamwork, Listeria monocytogenes recruits a silent ally during infection — an embedded prophage that doesn’t destroy its host, but helps it thrive. Researchers in the Herskovits lab uncovered how this “active-lysogeny” enables the bacteria to escape immune defenses, thanks to tightly regulated phage genes that remain dormant just enough to avoid triggering destruction. Now, new research aims to decode the molecular switch behind this cooperation, revealing how temperature-sensitive regulation of a key phage protein could reshape our understanding of host–phage dynamics — and even inspire smarter phage therapies.